Advice

following a resubmission:

botulinum toxin A (Botox®) is accepted for restricted use within NHS Scotland.

Indication under review: Prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).

SMC restriction: use in adults with chronic migraine whose condition has failed to respond to ≥3 prior oral prophylactic treatments, where medication overuse has been appropriately managed.

In pooled analysis of the two pivotal phase III studies, botulinum toxin type A (Botox®) significantly reduced the frequency of headache days compared with placebo.

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Medicine details

Medicine name:
botulinum toxin A (Botox)
SMC ID:
692/11
Indication:
Prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).
Pharmaceutical company
Allergan Ltd
BNF chapter
Central nervous system
Submission type
Resubmission
Status
Restricted
Date advice published:
13 February 2017