following a resubmission:
botulinum toxin A (Botox®) is accepted for restricted use within NHS Scotland.
Indication under review: Prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).
SMC restriction: use in adults with chronic migraine whose condition has failed to respond to ≥3 prior oral prophylactic treatments, where medication overuse has been appropriately managed.
In pooled analysis of the two pivotal phase III studies, botulinum toxin type A (Botox®) significantly reduced the frequency of headache days compared with placebo.
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- Medicine name:
- botulinum toxin A (Botox)
- SMC ID:
- Prophylaxis of headaches in adults with chronic migraine (headaches on at least 15 days per month of which at least 8 days are with migraine).
- Pharmaceutical company
- Allergan Ltd
- BNF chapter
- Central nervous system
- Submission type
- Date advice published:
- 13 February 2017