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caffeine 5mg/ml solution for injection


Following a full submission

caffeine base 5mg/ml solution for injection is accepted for restricted use within NHS Scotland for the treatment of apnoea of prematurity.

Short-term studies have demonstrated the efficacy of caffeine on apnoeic episodes and one longer-term study has shown reduction in disabilities relevant to these infants. It should be restricted to use on the advice of specialists in neonatal paediatrics.

Prescribers should note that, although the SPC describes this product in terms of caffeine base (5mg/ml), the neonatal formulary and the British National Formulary for Children currently recommend prescribing the dose as caffeine citrate (equivalent to 10mg/ml).

Drug Details

Drug Name: caffeine 5mg/ml solution for injection
SMC Drug ID: 550/09
Manufacturer: Viridian Pharma Ltd (Cardinal Health)
Indication: Apnoea of prematurity
BNF Category:
Sub Category: 4.7 Analgesics
Submission Type: Full submission
Status: Restricted
Date Advice Published: 11 May 2009