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glyceryl trinitrate 0.4% (Rectogesic)


Following a third resubmission

glyceryl trinitrate 0.4% ointment (Rectogesic®) is not recommended for use within NHS Scotland for relief of pain associated with chronic anal fissure.

It was associated with very small improvements in pain scores compared with vehicle, and therefore little clinically significant effect.

The manufacturer did not present a sufficiently robust economic case to gain acceptance by SMC.

Drug Details

Drug Name: glyceryl trinitrate 0.4% (Rectogesic)
SMC Drug ID: 200/05
Manufacturer: ProStrakan
Indication: Relief of pain associated with chronic anal fissure
BNF Category:
Sub Category: 1.7 Local preparations for anal and rectal disorders
Submission Type: Resubmission
Status: Not Recommended
Date Advice Published: 11 February 2008

Archived Advice

Resubmission 12 March 2007
Resubmission 10 April 2006
Full submission 10 October 2005