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Archived: sodium oxybate 500mg/ml oral solution (Xyrem®)


Following a full submission.

Sodium oxybate (Xyrem) is not recommended for use within NHS Scotland for the treatment of cataplexy in adult patients with narcolepsy.

In two studies the median percent decrease in weekly cataplexy attacks ranged from 49% to 85% for the dose range included in the product licence. However, the economic case for this product was not demonstrated.

Drug Details

Drug Name: sodium oxybate 500mg/ml oral solution (Xyrem®)
SMC Drug ID: 246/06
Manufacturer: UCB Pharma Ltd
Indication: Cataplexy in adult patients with narcolepsy
BNF Category:
Submission Type: Full submission
Status: Not Recommended
Date Advice Published: 10 April 2006

Current Advice

Resubmission 10 September 2007