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aztreonam lysine (Cayston)

Advice

following a re-submission considered under the orphan process

aztreonam lysine (Cayston®) is accepted for restricted use within NHS Scotland.

Indication under review: Suppressive therapy of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis aged six years and older.

SMC restriction: When inhaled colistimethate sodium and inhaled tobramycin are not tolerated or not providing satisfactory therapeutic benefit (measured as ≥2% decline in forced expiratory volume in 1 second [FEV1]).

Aztreonam lysine has demonstrated superiority in improving lung function and respiratory symptoms in one active-controlled study and two 28-day placebo-controlled studies in patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection.

This advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost effectiveness of aztreonam lysine. It is contingent upon the continuing availability of the Patient Access Scheme in NHS Scotland or a list price that is equivalent or lower.

This advice takes account of the views from a Patient and Clinician Engagement (PACE) meeting.

Drug Details

Drug Name: aztreonam lysine (Cayston)
SMC Drug ID: 753/12
Manufacturer: Gilead Sciences Ltd
Indication: Suppressive therapy of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis aged six years and older.
BNF Category:
Sub Category: 5.1 Antibacterial drugs
Submission Type: Resubmission
Status: Restricted
Date Advice Published: 12 January 2015

Archived Advice

Full submission 13 February 2012

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