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tipranavir (Aptivus) 250mg soft capsule

Advice

Following an abbreviated submission

tipranavir 250mg soft capsules (Aptivus ) in combination with low dose ritonavir are accepted for restricted use within NHS Scotland for combination antiretroviral treatment of HIV-1 infection in highly pre-treated adolescents 12 years of age or older with virus resistant to multiple protease inhibitors.

The marketing authorisation for tipranavir states that it should only be used as part of an active combination antiretroviral regimen in patients with no other therapeutic options. In adult patients the Scottish Medicines Consortium has restricted tipranavir to patients with a tipranavir mutation score of less than 4 and this restriction should also apply to this licence extension covering adolescents 12 years of age and older. Tipranavir is listed in the British National Formulary for Children for the treatment of HIV infection.

Drug Details

Drug Name: tipranavir (Aptivus) 250mg soft capsule
SMC Drug ID: 616/10
Manufacturer: Boehringer Ingelheim Ltd
Indication: HIV-1 infection in highly pre-treated adolescents 12 years of age or older with virus resistant to multiple protease inhibitors
BNF Category:
Sub Category: 5.3 Antiviral Drugs
Submission Type: Abbreviated Submission
Status: Restricted
Date Advice Published: 8 February 2010

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