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Archived: extended-release epidural morphine sulfate (Depodur)

Advice

Following a full submission

extended-release epidural morphine (Depodur) is not recommended for use within NHS Scotland for the relief of post-operative pain following major orthopaedic, abdominal or pelvic surgery.

Extended-release epidural morphine has shown some advantages in terms of efficacy versus a single-dose of epidural opioid. Evidence for clinical efficacy was obtained from studies that do not reflect current practice for epidural analgesia in NHS Scotland.

The manufacturer did not present a sufficiently robust clinical or economic analysis to gain acceptance by the SMC.

The licence holder has indicated their intention to resubmit

Drug Details

Drug Name: extended-release epidural morphine sulfate (Depodur)
SMC Drug ID: 528/09
Manufacturer: Flynn Pharma Ltd
Indication: relief of postoperative pain following major orthopaedic, abdominal or pelvic surgery
BNF Category:
Sub Category: 4.7 Analgesics
Submission Type: Full submission
Status: Not Recommended
Date Advice Published: 9 February 2009

Current Advice

Resubmission 8 March 2010

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