miconazole (Loramyc)

Advice

following a re-submission:

miconazole muco-adhesive buccal tablet (Loramyc®) is not recommended for use within NHS Scotland.

Indication under review: The treatment of oropharyngeal candidiasis (OPC) in immunocompromised patients.

Miconazole muco-adhesive buccal tablets were shown to be non-inferior in the treatment of OPC to another locally-acting miconazole preparation in patients with cancer of the head and neck who had received radiotherapy, and to another locally-acting anti-fungal in HIV-positive patients. There are no data comparing miconazole buccal tablets to treatments currently used in practice in Scotland in this patient group.

Overall the manufacturer did not present a sufficiently robust clinical and economic analysis to gain acceptance by SMC.