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sitagliptin (Januvia)


Following a full submission

sitagliptin (Januvia®) is accepted for restricted use within NHS Scotland for treatment of patients with type 2 diabetes mellitus to improve glycaemic control in combination with metformin when diet and exercise, plus metformin, do not provide adequate glycaemic control. It should be restricted to use in patients only when the addition of sulphonylureas is not appropriate, and represents an alternative to other agents such as thiazolidinediones.

Efficacy, as assessed by measurement of HbA1c, is similar to sulphonylurea and thiazolidinedione drugs added at this stage in therapy. It appears to have minimal effects on body weight.

Drug Details

Drug Name: sitagliptin (Januvia)
SMC Drug ID: 408/07
Manufacturer: MSD
Indication: Type 2 diabetes
BNF Category:
Sub Category: 6.1 Drugs used in diabetes
Submission Type: Full submission
Status: Restricted
Date Advice Published: 8 October 2007