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Archived: levetiracetam 250, 500, 750 and 1000mg tablets and levetiracetam oral solution 100mg/ml (Keppra)

Advice

Following a full submission

levetiracetam (Keppra®) is not recommended for use within NHS Scotland as adjunctive therapy in the treatment of partial onset seizures with or without secondary generalisation in children from 4 years of age with epilepsy.

In the pivotal study, levetiracetam reduced partial seizure frequency compared to placebo in both the treatment and evaluation phases.

The manufacturer did not present a sufficiently robust economic analysis to gain acceptance by SMC. The licence holder has indicated their decision to resubmit.

Drug Details

Drug Name: levetiracetam 250, 500, 750 and 1000mg tablets and levetiracetam oral solution 100mg/ml (Keppra)
SMC Drug ID: 394/07
Manufacturer: UCB Pharma Ltd
Indication: Adjunctive therapy in the treatment of partial onset seizures with or without secondary generalisation in children from 4 years of age with epilepsy
BNF Category:
Sub Category: 4.8 Antiepileptic drugs
Submission Type: Full submission
Status: Not Recommended
Date Advice Published: 10 September 2007

Current Advice

Resubmission 11 February 2008

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